A third baby has been born using the maternal spindle transfer method, as part of the pilot study conducted by the scientific team of the Institute of Life and Embryotools in Greece.In the context of this pilot study, the maternal spindle transfer is being researched as a means to treat infertility problems deriving from cytoplasmic dysfunction of the oocytes and to prevent transmission of serious inherited mitochondrial diseases.
The infant was born at 07:50 am on May 28, 2020, at IASO Hospital, to a Greek mother with a long history of multiple IVF failures. Both the mother and the infant are in very good health.
Attending obstetrician/gynecology surgeon Dr. Panagiotis Polyzos issued the following statement: “It is the most pleasant conclusion to a very complicated medical case, as this womanhad not managed to have her embryos reach the blastocyst stage to date, despite multiple IVF efforts.”
In a joint statement, Dr. Nuno Costa-Borges, Co-Founder of Embryotools, and Mr. Eros Nikitos, Director of the IASO Institute of Life Embryology Lab, said: “It is a major milestone for our pilot study. In this medical case, the total number of oocytes to be fertilized was separated. Half of the oocytes underwent the maternal spindle transfer method and the others were fertilized as they were, without the use of the method. The result completely justified our high expectations about the clinical study, as 4 of the oocytes which underwent the maternal spindle transfer method were fertilized and reached the blastocyst stage, while out of the rest of the fertilized oocytes, that did not undergo the maternal spindle transfer method, none of them reached such a stage. Following the embryotransfer of one blastocyst, pregnancy was achieved and a healthy infant was born.
Significant scientific publications will follow with all our latest research findings.”
The births of the first two babies using the maternal spindle transfer method in the context of the specific pilot study, were performed in Greece by the Institute of Life and Embryotools scientific team, in April and November 2019. The babies are now thirteen and seven months old, are monitored based on the clinical study protocol and are in excellent health.
Another 2 pregnancies as part of the clinical study on the maternal spindle transfer method are in an advanced stage.
About the pilot study on the Maternal Spindle Transfer Method
The pilot study on the maternal spindle transfer method involves mitochondrial replacement in human oocytes, fully preserving the genetic material of the woman who wants to reproduce. In this way, in the context of the pilot study being carried out by the Institute of Life and Embryotools, the scientific team is researching the potential of addressing the problems of women with fertility issues and multiple IVF failures caused by cytoplasmic dysfunctions of their oocytes, and the potential of addressing serious mitochondrial diseases.
Births of children using the maternal spindle transfer method are performed in the context of an ongoing research protocol concerning a pilot study that leads to pregnancy, which is conducted in accordance with the terms and conditions of Law 3305/2005. Based on current scientific findings, the maternal spindle transfer method is not an established infertility treatment, nor a recognized method of medically assisted reproduction.